A lab assistant absorbs Quinn’s personality as the result of a malevolent scientist’s experiment, and helps the Sliders battle the scientist before he can carry out an experiment that will cause the death of billions of innocent people.
Diana finds a powerful fusion generator with which she hopes to separate the two Quinns, but instead she inadvertently brings the malevolent Dr. Geiger back into the world.
The Sliders travel to a remote island where a group of monk-like people keep the world’s knowledge safe from a race of barbarians who have taken over the planet.
Mallory becomes the leader of a strange cult whose members are controlled by a man- made virus that takes away their individuality and transforms them into mere cells in a larger spiritual entity.
In a parallel Los Angeles, the press is only interested in tabloid trash, and Maggie becomes embroiled in a phony affair with the President of the United States to cover up the very real war America is waging against Switzerland.
The Sliders leap into a prohibition-era America where caffeine is an illegal drug, cops are controlled by mobsters and underground coffeehouses flourish.
The Sliders land in a parallel of Maggie’s hometown, where her duplicate is celebrated as a heroic space traveller who had tragically disappeared on a flight to Mars.
In a vast desert wasteland where combustion engines have been outlawed, Mallory joins a rebel gang of motorcycle riders that steal petroleum from a powerful conglomerate.
Rembrandt becomes telepathically linked to a friend he lost long ago who is now being used by the Kromaggs as a sinister kind of human computer to help them destroy the human race.
At a sinister health facility, Diana is subjected to a brain remapping procedure that gives her strange telekinetic powers but also sends her mind into a kind of void, rendering her unable to communicate with her friends.
The Sliders land at a high-tech pleasure resort which offers realistic games featuring action scenarios, but they discover that the holographic people in the games are powered by real human minds trapped by the sinister owner of the resort.
In a world where modern technology is unheard of and pirates still sail the open seas, the Sliders must find their way back to the slide zone before time runs out.
The Sliders arrive in the midst of a film festival with their timer severely malfunctioning, and the only way to repair it is to steal a costly jewel worn by one of the wealthy celebrities at the festival.
The Sliders come upon an archaeologist excavating ancient ruins and realize that the earth as they know it was destroyed four hundred years ago in this world.
The Sliders find themselves trapped in a world that is swiftly collapsing in on itself, having been lured there by Diana’s former mentor, Dr Oberon Geiger.
The Sliders discover they are the subjects of a fanatical religion known as Slidology, founded by a man with psychic powers who has been able to follow them on their interdimensional adventures in his mind.